The Influence of Silver Nanoparticles Made in Chitosan Area on MMP-9 in Experimental Models of Chronic Bronchitis

Abstract

According to the World Health Organization in 2017, chronic respiratory diseases (CRDs) are one of the major challenges to global public health. One-sixth of all common deaths from CRD have been linked to chronic obstructive pulmonary diseases (COPD). The use of nanoparticles in the last decade has gained widespread recognition in biology and medicine. Among them, silver nanoparticles (AgNPs) have a special place due to their unique properties.The aim of the study is to detect the influence of silver nanoparticles made in chitosan area on MMP-9 in experimental models of chronic bronchitis. To reach this, we set a several tasks. In research, we use an innovative method of treatment, that is relatively new in practice. During the experiment, we created a silver nanoparticle and a chitosan nanocompound by “Green Technology”.during of the experiment, an effective compound was developed, and it had positive effect on experimental rats in the treatment of chronic bronchitis. We believe that the antioxidant properties of silver nanoparticles and chitosan will reduce the negative effects of metalloproteinases on lung tissue, which will prevent the risk of developing chronic bronchitis. This will make it possible to effectively manage the complications of CBD, reduce mortality, and improve treatment costs as well as improve quality of life and ability to work.this study has not been completed at this stage and itis in process at Natishvili Morphology Institute, equipped with a biochemistry laboratory. The final results are being analyzed at this time.